By P. D. Aplan, M. Stanulla (auth.), Prof. Dr. T. Büchner, Prof. Dr. med. W. Hiddemann, Prof. Dr. B. Wörmann, Prof. Dr. G. Schellong, Prof. Dr. J. Ritter, Prof. Dr. U. Creutzig (eds.)

ISBN-10: 3642181562

ISBN-13: 9783642181566

ISBN-10: 3642621090

ISBN-13: 9783642621093

Since 1987 Acute Leukemias (AL) has on a regular basis said at the cutting-edge within the swiftly turning out to be, winning and interesting box of biology and administration of those illnesses. during this quantity huge multicenter scientific trials back shape the cast foundation for the research of leukemic mobilephone biology, the detection of biologic subgroups, their differential reaction to replacement therapy concepts and the additional improvement of remedy. specifically, this quantity addresses mechanisms of chromosomal translocations and transcription elements, risk-adapted therapy innovations, differentiation remedy, secondary AL, designated facets in older sufferers, and adoptive immunotherapy. in addition to the antileukemic techniques, supportive remedy with new antimicrobial elements and development elements is up-to-date. As a discussion board of globally actions within the box of AL this quantity includes either exhaustive overviews on significant scientific concerns and initial facts and hypotheses no longer formerly published.

Show description

Read Online or Download Acute Leukemias VIII: Prognostic Factors and Treatment Strategies PDF

Similar nonfiction_10 books

Download e-book for kindle: Continuous Ambulatory Peritoneal Dialysis by R. Gokal (auth.), G. R. D. Catto DSc, MD, FRCP (Lond., Edin.

For greater than a iteration haemodialysis has been the critical approach to treating sufferers with either acute and persistent renal failure. in the beginning, advancements and enhancements within the procedure have been hugely technical and suitable to simply a comparatively small variety of experts in nephrology. extra lately, as advances in treatment have dem­ onstrated the price of haemofiltration within the in depth treatment unit and haemoperfusion for particular types of poisoning, the fundamental rules of haemodialysis were perceived as vital in lots of parts of medical perform.

New PDF release: Ion-Molecule Reactions: Volume 1

After a number of faint stirrings of curiosity in ion-molecule reactions throughout the early days of mass spectrometry, the topic used to be nearly thoroughly overlooked for a few years. there has been a renascence of curiosity within the topic following pioneering experiments by means of Tal'roze in Russia and independently by means of Steven­ son and Schissler and box, Franklin, and Lampe during this nation.

Additional info for Acute Leukemias VIII: Prognostic Factors and Treatment Strategies

Example text

STEWART 2, G. LOWTHER2, C. SCHOLL l, S. FROHLINGl,A. c. TSUI4, P. SCHERER 4 and H. DOHNER l Introduction Cytogenetic studies have shown loss of chro mosome 7 (-7) or deletions of the long arm (7q-) in various tumor types . These findings suggest that chromosome 7 harbours tumor suppressor genes which play a role in the pathogenesis of these malignancies (Atkin et al. 1993; Zenklusen et al. 1996). In particular, in myeloid disorders loss of -7I7q- are among the most frequent chromosome abnormalities.

References Atkin NB, Baker MC (1993): Chromosome 7q deletions: observation on 13 malignant tumors. Cancer Genet Cytogenet 67:123-125 Bloomfield CD and de la Chapelle A (1987) Chromosome abno rmalit ies in acute nonlymphocytic leukemia: Clinical and biological significance. Semin OncoI14:372-383 Cohen D, Chumakov I, Weissenbach J (1993) A first generat ion physical map of the human genome. 5 and 7. J Clin OncoI3 :325-345 Dohner K, Brown J, Hehmann U, Hetzel C, Stewart J, Lowther G, Scholl C, Prohling S, Cuneo A, Tsui LC, Lichter P, Scherer SW, Dohner H (1998) Molecular cytogenetic characterization of a critical region in bands 7q35-q36 commonly deleted in malignant myeloid disorders .

Garner MM, and Felsenfeld G (1987). Effect of Z-DNA on nucleosome placement. Journal of Molecular Biology 196, 581-90. Grawunder U,West RB, and Lieber MR (1998). Antigen receptor gene rearrangement. Current Opinion in Immunology 10, 172-180. Grignani F,Fagioli M, Alcalay M, Longo L, Pandolfi PP, Donti E, Biondi A, Lo Coco F, Grignani F,and Pelicci PG (1994). Acute promyelocytic leukemia: from genetics to treatment. Blood 83, 10-25. Grimwade 0, Walker H, Oliver F,Wheatley K, Harrison C, Harrison G, Rees J, Hann I, Stevens R, Burnett A, and Goldstone A (1998).

Download PDF sample

Acute Leukemias VIII: Prognostic Factors and Treatment Strategies by P. D. Aplan, M. Stanulla (auth.), Prof. Dr. T. Büchner, Prof. Dr. med. W. Hiddemann, Prof. Dr. B. Wörmann, Prof. Dr. G. Schellong, Prof. Dr. J. Ritter, Prof. Dr. U. Creutzig (eds.)


by Edward
4.4

Rated 4.88 of 5 – based on 49 votes