By P. D. Aplan, M. Stanulla (auth.), Prof. Dr. T. Büchner, Prof. Dr. med. W. Hiddemann, Prof. Dr. B. Wörmann, Prof. Dr. G. Schellong, Prof. Dr. J. Ritter, Prof. Dr. U. Creutzig (eds.)

ISBN-10: 3642181562

ISBN-13: 9783642181566

ISBN-10: 3642621090

ISBN-13: 9783642621093

Since 1987 Acute Leukemias (AL) has on a regular basis said at the cutting-edge within the swiftly turning out to be, winning and interesting box of biology and administration of those illnesses. during this quantity huge multicenter scientific trials back shape the cast foundation for the research of leukemic mobilephone biology, the detection of biologic subgroups, their differential reaction to replacement therapy concepts and the additional improvement of remedy. specifically, this quantity addresses mechanisms of chromosomal translocations and transcription elements, risk-adapted therapy innovations, differentiation remedy, secondary AL, designated facets in older sufferers, and adoptive immunotherapy. in addition to the antileukemic techniques, supportive remedy with new antimicrobial elements and development elements is up-to-date. As a discussion board of globally actions within the box of AL this quantity includes either exhaustive overviews on significant scientific concerns and initial facts and hypotheses no longer formerly published.

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STEWART 2, G. LOWTHER2, C. SCHOLL l, S. FROHLINGl,A. c. TSUI4, P. SCHERER 4 and H. DOHNER l Introduction Cytogenetic studies have shown loss of chro mosome 7 (-7) or deletions of the long arm (7q-) in various tumor types . These findings suggest that chromosome 7 harbours tumor suppressor genes which play a role in the pathogenesis of these malignancies (Atkin et al. 1993; Zenklusen et al. 1996). In particular, in myeloid disorders loss of -7I7q- are among the most frequent chromosome abnormalities.

References Atkin NB, Baker MC (1993): Chromosome 7q deletions: observation on 13 malignant tumors. Cancer Genet Cytogenet 67:123-125 Bloomfield CD and de la Chapelle A (1987) Chromosome abno rmalit ies in acute nonlymphocytic leukemia: Clinical and biological significance. Semin OncoI14:372-383 Cohen D, Chumakov I, Weissenbach J (1993) A first generat ion physical map of the human genome. 5 and 7. J Clin OncoI3 :325-345 Dohner K, Brown J, Hehmann U, Hetzel C, Stewart J, Lowther G, Scholl C, Prohling S, Cuneo A, Tsui LC, Lichter P, Scherer SW, Dohner H (1998) Molecular cytogenetic characterization of a critical region in bands 7q35-q36 commonly deleted in malignant myeloid disorders .

Garner MM, and Felsenfeld G (1987). Effect of Z-DNA on nucleosome placement. Journal of Molecular Biology 196, 581-90. Grawunder U,West RB, and Lieber MR (1998). Antigen receptor gene rearrangement. Current Opinion in Immunology 10, 172-180. Grignani F,Fagioli M, Alcalay M, Longo L, Pandolfi PP, Donti E, Biondi A, Lo Coco F, Grignani F,and Pelicci PG (1994). Acute promyelocytic leukemia: from genetics to treatment. Blood 83, 10-25. Grimwade 0, Walker H, Oliver F,Wheatley K, Harrison C, Harrison G, Rees J, Hann I, Stevens R, Burnett A, and Goldstone A (1998).

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Acute Leukemias VIII: Prognostic Factors and Treatment Strategies by P. D. Aplan, M. Stanulla (auth.), Prof. Dr. T. Büchner, Prof. Dr. med. W. Hiddemann, Prof. Dr. B. Wörmann, Prof. Dr. G. Schellong, Prof. Dr. J. Ritter, Prof. Dr. U. Creutzig (eds.)

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